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Synovial Fluid Analysis to Identify Osteoarthritis

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

High serum levels of galectins 1 and 4 in osteoarthritis patients

Priscilla Stela Santana de Oliveira¹, Pablo Ramon Gualberto Cardoso¹, Simão Kalebe de Paula Silva¹

¹Laboratory of Immunomodulation and New Therapeutic Approaches (LINAT), Suely-Galdino Therapeutic Innovation Research Center (NUPIT-SG), Federal University of Pernambuco (UFPE), Recife, PE, Brazil.

Clinical Biochemistry

|March 1, 2023

Abstract

Background:

Although immunostaining of galectins is associated with cartilage damage, the serum levels of these lectins in osteoarthritis (OA) are not fully understood.

Objective:

Therefore, we evaluate the concentrations of galectins-1, 3, 4, and 7 in patients with osteoarthritis and correlate them with clinical parameters.

Methods:

This cross-sectional study involved 60 osteoarthritis patients and 43 healthy volunteers, who had serum samples collected for galectins titration by Enzyme-Linked Immunosorbent Assay (ELISA).

Results:

Our finds showed that the median values of gal-1 and 4 serum levels in patients were statistically higher (13,990 and 969.1 pg/mL, respectively) than in healthy controls (1,798 and 519.5 pg/mL) with p < 0.001. Further, gal-1 expressed higher levels in patients who had joint edema at the time of collection with a median value of 14,970 pg/mL.

Conclusion:

Surprisingly, galectin-4 appears to be involved in the osteoarthritis inflammation process as the well-known galectin-1.

Keywords:

Cartilage ECM Glycans Joint

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