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Tungsten toxicity and carcinogenesis.

Alicia M Bolt1

  • 1College of Pharmacy, Department of Pharmaceutical Sciences, The University of New Mexico, Albuquerque, NM, United States.

Advances in Pharmacology (San Diego, Calif.)
|March 1, 2023
PubMed
Summary

Tungsten exposure poses health risks, especially when combined with other metals. Understanding tungsten

Area of Science:

  • Environmental toxicology
  • Occupational health
  • Metal toxicology

Background:

  • Tungsten is an emerging environmental contaminant due to industrial applications.
  • Human exposure levels can be high in specific occupational and environmental settings.
  • The complex toxicity profile of tungsten, including its synergistic effects with co-exposures, requires further investigation.

Purpose of the Study:

  • To review the current state of tungsten toxicology research.
  • To examine tungsten's carcinogenicity and other major toxicities (pulmonary, cardiometabolic, bone, immune).
  • To discuss environmental and human monitoring data to identify at-risk populations and exposure levels.

Main Methods:

  • Literature review of existing tungsten toxicology studies.
Keywords:
BiomonitoringBoneCarcinogenesisMetalToxicityTumorigenesisTungsten

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  • Analysis of data on tungsten exposure in environmental and human monitoring.
  • Synthesis of research on tungsten's effects alone and in combination with other metals, particularly cobalt.

    • Main Results:

    • Tungsten's toxicity is complex and can be augmented by co-exposures, leading to more severe health outcomes.
    • Research is ongoing into tungsten's carcinogenic potential and its impact on pulmonary, cardiometabolic, bone, and immune systems.
    • Environmental and human data highlight specific populations at higher risk due to tungsten exposure.

    Conclusions:

    • Further research is crucial to fully understand the human health risks associated with tungsten exposure.
    • The synergistic effects of tungsten with other metals necessitate a comprehensive approach to risk assessment.
    • Identifying and monitoring high-risk populations is essential for mitigating potential adverse health effects from tungsten.