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miRNAs and arsenic-induced carcinogenesis

Alexandra N Nail1, Ana P Ferragut Cardoso1, Lakyn K Montero1

  • 1Department of Pharmacology and Toxicology, Center for Integrative Environmental Health Science, University of Louisville, Louisville, KY, United States.

Advances in Pharmacology (San Diego, Calif.)
|March 1, 2023
PubMed

Insights

Arsenic exposure causes cancer worldwide. This review details how microRNA (miRNA) changes contribute to arsenic-induced cancers, aiding in developing new treatments.

Area of Science:

  • Environmental Health Sciences
  • Molecular Biology
  • Cancer Research

Background:

  • Arsenic-induced carcinogenesis is a significant global health concern.
  • Understanding the molecular drivers of arsenic-related cancers is crucial for effective treatment strategies.
  • MicroRNA (miRNA) dysregulation is increasingly recognized as a key factor in cancer development and progression.

Approach:

  • This chapter comprehensively reviews the current literature on miRNA dysregulation in arsenic-induced cancers.
  • It examines studies linking altered miRNA expression in individuals with chronic arsenic exposure to cancer development.
  • The review also includes findings from cell models investigating arsenic-induced carcinogenesis.

Key Points:

  • Altered miRNA expression is consistently observed in cancers associated with chronic arsenic exposure.
  • miRNA dysregulation plays a role in the molecular mechanisms underlying arsenic-induced carcinogenesis.
  • Specific miRNAs may serve as biomarkers or therapeutic targets for arsenic-related cancers.

Conclusions:

  • miRNA dysregulation is a critical component of arsenic-induced carcinogenesis.
  • Further research into miRNA's role can lead to novel diagnostic and therapeutic approaches for arsenic-related cancers.
  • Addressing miRNA alterations presents a promising avenue for combating arsenic-induced cancer globally.
Keywords:
ArsenicBladderCancerChronicKidneyLungProstateSkinmiRNA

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