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Syphilitic Hepatitis: A Rare Cause of Elevated Liver Function Tests
Shaharyar Salim1, Rabeea Farhan2, Asif Surani3
1Department of Internal Medicine, Aga Khan University Hospital, Karachi, PAK.
Cureus
|March 2, 2023
Summary
Syphilitic hepatitis, a rare syphilis manifestation, can cause elevated liver function tests. Prompt diagnosis and treatment with penicillin led to full recovery in a healthy patient.
Area of Science:
- Hepatology
- Infectious Diseases
- Dermatology
Background:
- Syphilitic hepatitis is an uncommon presentation of syphilis.
- It can manifest with abnormal liver function tests (LFTs).
Observation:
- A 28-year-old immunocompetent male presented with symptoms suggestive of hepatitis.
- Physical exam revealed abdominal tenderness and a genital chancre.
- Laboratory tests showed elevated liver enzymes and reactive RPR with positive treponemal antibodies.
Findings:
- The patient was diagnosed with syphilitic hepatitis.
- He received treatment with benzathine penicillin.
- Symptoms and LFTs resolved completely within one week.
Implications:
- Syphilitic hepatitis should be considered in the differential diagnosis of elevated LFTs.
- A comprehensive sexual history and genital examination are crucial for diagnosis.
- Early diagnosis and treatment prevent significant morbidity.
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