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Syphilitic Hepatitis: A Rare Cause of Elevated Liver Function Tests.

Shaharyar Salim1, Rabeea Farhan2, Asif Surani3

  • 1Department of Internal Medicine, Aga Khan University Hospital, Karachi, PAK.

Cureus
|March 2, 2023
PubMed
Summary

Syphilitic hepatitis, a rare syphilis manifestation, can cause elevated liver function tests. Prompt diagnosis and treatment with penicillin led to full recovery in a healthy patient.

Keywords:
deranged liver function testhepatic enzymeshepatic manifestationsinfectious hepatitisliver function test (lft)sexual transmitted diseasessexually transmitted infection (sti)syphilistreponema pallidum

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Dermatology

Background:

  • Syphilitic hepatitis is an uncommon presentation of syphilis.
  • It can manifest with abnormal liver function tests (LFTs).

Observation:

  • A 28-year-old immunocompetent male presented with symptoms suggestive of hepatitis.
  • Physical exam revealed abdominal tenderness and a genital chancre.
  • Laboratory tests showed elevated liver enzymes and reactive RPR with positive treponemal antibodies.

Findings:

  • The patient was diagnosed with syphilitic hepatitis.
  • He received treatment with benzathine penicillin.
  • Symptoms and LFTs resolved completely within one week.

Implications:

  • Syphilitic hepatitis should be considered in the differential diagnosis of elevated LFTs.
  • A comprehensive sexual history and genital examination are crucial for diagnosis.
  • Early diagnosis and treatment prevent significant morbidity.