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Updated: Aug 8, 2025

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
Published on: February 14, 2021
[Research Progressin the Relationship between Interleukin-6 and Intervertebral Disc Degeneration]
Jin-Lei Chen1, Shuang Wang2, Ming-Chuan Wang1
1The First Clinical Medical School of Lanzhou University,Lanzhou 730000,China.
Abstract:
Intervertebral disc degeneration (IDD) is one of the main diseases causing low back pain,which seriously affects the quality of life of patients.Recent studies have discovered that interleukin-6 (IL-6) is highly expressed in the tissues and cells of degenerative intervertebral disc and is closely related to the occurrence and development of IDD.However,the signaling pathway and role of IL-6 in IDD remain to be understood.Therefore,this article reviews the recent studies about the signaling pathway and role of IL-6 in IDD,aiming to facilitate the clinical work and subsequent research progress.

