Transperineal vs. transrectal biopsy to reduce postinterventional sepsis
Judith Stangl-Kremser1, Ashwin Ramaswamy, Jim C Hu
1Department of Urology, Weill Cornell Medicine, New York, New York, USA.
Current Opinion in Urology
|March 2, 2023
Summary
Transperineal prostate biopsy is increasingly favored over transrectal biopsy due to significantly lower rates of dangerous sepsis. This review supports offering transperineal biopsy as a standard option for men undergoing prostate cancer diagnosis.
Area of Science:
- Urology
- Infectious Disease
- Oncology
Background:
- Prostate biopsy is a key diagnostic tool for prostate cancer.
- Traditionally, transrectal prostate biopsy has been standard, but carries infectious risks.
- Transperineal prostate biopsy offers a lower infectious risk profile.
Conclusions:
- The transperineal approach is increasingly adopted due to lower sepsis rates.
- Recent literature supports the practice change towards transperineal biopsy.
- Transperineal biopsy should be offered as an option to all men.


