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Irisin in domestic animals.
E Lai1, S Unniappan1
1Department of Veterinary Biomedical Sciences, Laboratory of Integrative Neuroendocrinology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada.
Domestic Animal Endocrinology
|March 2, 2023
Summary
Irisin, a hormone from fibronectin type III domain-containing protein, aids energy expenditure and fat browning in vertebrates. Further research into irisin in domestic animals may yield new therapeutic agents and biomarkers.
Area of Science:
- Endocrinology
- Veterinary Medicine
- Molecular Biology
Background:
- Irisin is a peptide hormone derived from the fibronectin type III domain-containing protein.
- It plays a role in browning white adipose tissue and increasing energy expenditure.
- Irisin is conserved across vertebrates, indicating shared functions in domestic animals.
Purpose of the Study:
- To review the current understanding of irisin structure, tissue distribution, and functions in vertebrates.
- To focus on the relevance of irisin in mammals significant to veterinary medicine.
- To explore irisin's potential as a therapeutic agent and biomarker in domestic animal endocrinology.
Main Methods:
- Literature review of existing studies on irisin.
- Analysis of irisin's presence and function across different vertebrate species.
- Synthesis of information regarding irisin's role in domestic animal physiology.
Main Results:
- Irisin is found in various tissues beyond plasma and muscle, including adipose tissue, liver, kidney, and more.
- Its presence suggests functions beyond energy expenditure regulation.
- The review consolidates current knowledge on irisin in vertebrates, with an emphasis on domestic animals.
Conclusions:
- Irisin's widespread tissue distribution indicates diverse physiological roles.
- Understanding irisin in domestic animals is advancing.
- Irisin holds promise for developing novel therapeutic strategies and diagnostic biomarkers in veterinary endocrinology.
