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The correlation between T-wave abnormalities and adverse cardiovascular events and echocardiographic changes in

Shengnan Liu1, Chao Zhang1, Jing Wan1

  • 1Zhongnan Hospital of Wuhan University, Wuhan City, China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|March 2, 2023
PubMed

Insights

Hypertensive patients with abnormal electrocardiogram (ECG) T-waves have a higher risk of major adverse cardiovascular events (MACE). Echocardiographic markers of cardiac structure were also significantly elevated in these patients, indicating increased cardiovascular risk.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Medical Diagnostics

Background:

  • Major adverse cardiovascular events (MACE) are prevalent in hypertensive individuals, contributing to elevated mortality rates.
  • Hypertension is a significant risk factor for cardiovascular disease, necessitating early detection and management of complications.

Purpose of the Study:

  • To investigate the incidence of MACE in patients with hypertension.
  • To explore the correlation between electrocardiogram (ECG) T-wave abnormalities and echocardiographic changes in hypertensive patients.

Main Methods:

  • A retrospective cohort study involving 430 hypertensive patients over a six-year period.
  • Patients were categorized based on the presence or absence of ECG T-wave abnormalities.
  • Analysis included incidence of adverse cardiovascular events and changes in echocardiographic parameters.

Main Results:

  • Hypertensive patients with abnormal T-waves exhibited a significantly higher incidence of MACE compared to those with normal T-waves (69.4% vs. 54.9%).
  • Elevated echocardiographic markers of cardiac structure, including ascending aorta diameter, left atrial diameter, and interventricular septal thickness, were observed in the abnormal T-wave group.
  • Age, hypertension duration, premature atrial beats, and severe valvular regurgitation were identified as significant predictors of MACE in Cox regression analysis.

Conclusions:

  • Abnormal T-waves in hypertensive patients are associated with an increased risk of major adverse cardiovascular events.
  • The study highlights the utility of ECG T-wave abnormalities as a potential indicator of structural cardiac changes and heightened cardiovascular risk in hypertensive individuals.
Abstract

Keywords:
HypertensionT-wave abnormalitiesadverse cardiovascular eventechocardiogram

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