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Risk factors for totally implantable access ports-associated thrombosis in pediatric oncology patients

Yingxia Lan1,2, Liuhong Wu1,2, Jin Guo1,3

  • 1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, Guangdong, People's Republic of China.

Scientific Reports
|March 2, 2023
PubMed

Insights

Totally implantable access ports (TIAPs) are common in pediatric oncology. Key risk factors for TIAPs-associated thrombosis include platelet count, C-reactive protein, and catheter tip distance, necessitating closer monitoring.

Area of Science:

  • Medical Oncology
  • Pediatric Hematology/Oncology
  • Vascular Access Devices

Background:

  • Totally implantable access ports (TIAPs) reduce treatment discomfort but carry risks.
  • TIAPs-associated thrombosis is a common complication, particularly in pediatric oncology.
  • Risk factors for TIAPs-associated thrombosis in children remain incompletely understood.

Purpose of the Study:

  • To identify risk factors for TIAPs-associated thrombosis in pediatric oncology patients.
  • To investigate the role of internal jugular vein distance as a potential risk factor.
  • To enhance understanding of thrombosis development in this patient population.

Main Methods:

  • Retrospective analysis of 587 pediatric oncology patients who underwent TIAPs implantation.
  • Measurement of the vertical distance from the catheter tip to the sternoclavicular border on chest X-rays.
  • Statistical analysis to determine significant risk factors for thrombosis.

Main Results:

  • 143 out of 587 patients (24.4%) developed TIAPs-associated thrombosis.
  • Platelet count, C-reactive protein levels, and catheter tip distance were significant risk factors.
  • Increased vertical distance of the catheter tip was associated with higher thrombosis risk.

Conclusions:

  • TIAPs-associated thrombosis is a frequent occurrence in pediatric cancer patients, including asymptomatic cases.
  • Catheter tip position, indicated by vertical distance, is a modifiable risk factor requiring attention.
  • Further research and clinical vigilance are warranted to mitigate TIAPs-associated thrombosis.

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