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Alcohol Drinking Patterns and Risk of Developing Acute and Chronic Pancreatitis
Ulrik Becker1, Amalie Timmermann1, Ola Ekholm1
1National Institute of Public Health, University of Southern Denmark, Studiestræde 6, Copenhagen DK-1455, Denmark.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|March 2, 2023
Summary
Alcohol consumption, including binge drinking and daily intake, increases the risk of acute and chronic pancreatitis. Beer and spirits appear more harmful than wine, with a J-shaped association observed between alcohol intake and pancreatitis risk.
Area of Science:
- Gastroenterology
- Epidemiology
- Public Health
Background:
- Alcohol consumption is a leading cause of pancreatitis.
- Understanding the specific drinking patterns and types of alcohol that influence pancreatitis risk is crucial for public health interventions.
Purpose of the Study:
- To investigate the association between alcohol drinking patterns, types of alcohol consumed, and the risk of developing acute and chronic pancreatitis.
- To analyze the dose-response relationship and identify specific risk factors within alcohol consumption.
Main Methods:
- A prospective cohort study involving 316,751 participants from Danish National Health Surveys (2010, 2013).
- Alcohol consumption data collected via self-reported questionnaires; pancreatitis diagnoses obtained from national health registers.
- Statistical analysis using Cox regression models, adjusting for potential confounders like smoking, BMI, diet, and education.
Main Results:
- A J-shaped association was observed between overall alcohol intake and pancreatitis risk, with increased risk in abstainers and heavy drinkers (>14 drinks/week).
- Frequent binge drinking and daily alcohol consumption were significantly associated with higher risks of both acute and chronic pancreatitis.
- High weekly intake of spirits (>14 drinks) and beer (>14 drinks) increased pancreatitis risk, while wine consumption showed no significant association.
Conclusions:
- Alcohol intake exhibits a J-shaped relationship with pancreatitis development.
- Daily drinking, binge drinking, and problematic alcohol use are linked to increased pancreatitis risk.
- The type of alcohol matters, with spirits and beer posing a greater risk than wine for pancreatitis.
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