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Related Experiment Video

Updated: Aug 8, 2025

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Author Spotlight: Advancing Large-Scale Neural Dynamics Through HD-MEA Technology

Published on: March 8, 2024

Macroscale coupling between structural and effective connectivity in the mouse brain.

Danilo Benozzo¹, Giorgia Baron¹, Ludovico Coletta²

¹Department of Information Engineering, University of Padova, Padova, Italy.

Biorxiv : the Preprint Server for Biology

|March 3, 2023

Summary

This summary is machine-generated.

The relationship between brain structure and function is complex. Strong structural connections do not always equate to strong functional connections, especially in higher-order brain areas.

Keywords:

directed structural connectivity dynamic causal modeling effective connectivity structural-effective coupling

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Last Updated: Aug 8, 2025

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Modeling the Functional Network for Spatial Navigation in the Human Brain

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Published on: October 13, 2023

Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Understanding the relationship between structural connectivity (SC) and functional connectivity (FC) in the brain is a fundamental challenge in neuroscience.
Existing research often reveals a lack of one-to-one correspondence between anatomical structure and observed brain activity patterns.

Approach:

This study utilized a directed structural connectome of the mouse brain derived from viral tracer data.
Effective connectivity (EC) matrices were computed from whole-brain resting-state fMRI data using a novel dynamic causal modeling (DCM) approach.
The coupling between SC and EC was analyzed by conditioning on the strongest links in both connectomes.

Key Points:

When focusing on the strongest effective connectivity (EC) links, the observed coupling aligns with the established unimodal-transmodal functional hierarchy.
Conversely, strong structural connectivity (SC) links within high-order cortical areas do not necessarily correspond to strong EC.
Significant mismatches between SC and EC are evident across different brain networks, with sensory-motor networks showing the best alignment.

Conclusions:

The findings highlight that the relationship between brain structure and function is not straightforward and is influenced by network properties and analytical approaches.
The study underscores the importance of considering directed structural information and the limitations of functional connectivity measures for a comprehensive understanding of brain network organization.