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Lysozyme-Induced Nephropathy: A Diagnosis Not to Forget
Núria Paulo1, Pedro Baptista2, Fernando Nogueira3
1Nephrology, Centro Hospitalar e Universitário de São João, Porto, PRT.
This case report details a patient with acute myeloid leukemia (AML) who developed acute kidney injury. Lysozyme-induced nephropathy was identified as the cause, and treatment led to recovery, emphasizing early diagnosis for better outcomes.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Hematologic malignancies, such as acute myeloid leukemia (AML), can present with diverse renal complications.
- Acute kidney injury (AKI) is a significant concern in patients with hematologic cancers, often multifactorial.
Observation:
- A 44-year-old female with newly diagnosed acute myeloid leukemia (AML) presented with acute kidney injury.
- Diagnostic workup suggested lysozyme-induced nephropathy as the primary cause of renal dysfunction.
Findings:
- The patient received intensive cytoreduction and chemotherapy.
- Treatment resulted in improvement of both hematologic parameters (cytopenias) and kidney function.
Implications:
- This case underscores the importance of considering lysozyme-induced nephropathy in AML patients with AKI.
- Early recognition and diagnosis of this specific kidney injury can positively influence patient prognosis and treatment strategies.
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