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Magnetoresponsive fluorescent core-shell nanoclusters for biomedical applications
Giovanni Marco Saladino1, Ronak Kakadiya1, Shaquib Rahman Ansari2
1Department of Applied Physics, Biomedical and X-ray Physics, KTH Royal Institute of Technology SE 10691 Stockholm Sweden saladino@kth.se.
Nanoscale Advances
|March 3, 2023
Summary
Superparamagnetic nanoclusters (SP-NCs) up to 400 nm were synthesized for enhanced biomedical applications. These SP-NCs exhibit high unit magnetization and heating efficiency, overcoming limitations of smaller superparamagnetic iron oxide nanoparticles.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Superparamagnetic iron oxide nanoparticles (SPIONs) are crucial in biomedicine for applications like drug delivery and hyperthermia.
- Conventional SPIONs (20-30 nm) have limited unit magnetization due to size constraints.
- There is a need for magnetic nanoparticles with improved properties for enhanced biomedical efficacy.
Purpose of the Study:
- To design and synthesize superparamagnetic nanoclusters (SP-NCs) with diameters up to 400 nm.
- To achieve high unit magnetization and enhanced loading capacity in SP-NCs.
- To investigate the influence of synthesis methods and capping agents on SP-NC properties.
Main Methods:
- Synthesized SP-NCs using conventional and microwave-assisted solvothermal methods.
- Employed citrate or l-lysine as capping agents to control size, surface chemistry, and magnetic properties.
- Coated SP-NCs with a fluorophore-doped silica shell for fluorescence and stability.
- Evaluated heating efficiency under an alternating magnetic field.
Main Results:
- Successfully synthesized SP-NCs up to 400 nm with high unit magnetization.
- Demonstrated that synthesis route and capping agent significantly impact particle size, surface chemistry, and magnetic properties.
- Achieved fluorescence in the near-infrared spectrum and high chemical/colloidal stability via silica coating.
- Observed promising heating efficiency for hyperthermia applications.
Conclusions:
- The developed SP-NCs offer enhanced magnetic properties and loading capacity compared to traditional SPIONs.
- Silica coating provides fluorescence and stability, broadening potential biomedical applications.
- The synthesized SP-NCs show significant potential for advanced biomedical applications, including hyperthermia treatment.
