Ionic Liquids Mediated Micellization of Pluronic Copolymers: Aggregation Behavior of Amphiphilic Triblock Copolymers

Understanding the micellization of amphiphilic triblock copolymers, especially Pluronics can play a persuasive role in engineering "smart" formulations for drug delivery applications. Their underlying self-assembly in the presence of designer solvents such as ionic liquids (ILs) provides combinatorial benefits of unique munificent properties of ILs and copolymers. The complex molecular interactions in the Pluronic copolymers/ILs mixed system influence the aggregation mechanism of copolymers depending on various aspects with no standardized factors to govern the structure-property relationship, which led to the practical applications. Here, we summarized recent progress in understanding the micellization process of IL-Pluronic mixed systems. Special emphasis was given to pure Pluronic systems (i.e., PEO-PPO-PEO) without any structural modifications, such as copolymerization with other functional groups, and ILs having cholinium and imidazolium groups. We expect that the correlation between existing/developing experimental and theoretical studies will provide the necessary basis and impetus for successful utilization in drug delivery applications.