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The importance of hsa-miR-28 in human malignancies

Seyede Fatemeh Hosseini1, Setareh Javanshir-Giv2, Hanieh Soleimani3

  • 1Faculty Member, Tabas School of Nursing, Birjand University of Medical Sciences, Birjand, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|March 3, 2023
PubMed

Insights

Dysfunctional microRNAs (miRNAs) drive cancer by affecting cell growth and spread. This review highlights miR-28-3p and miR-28-5p as potential diagnostic biomarkers for early cancer detection and prognosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNA (miRNA) production is frequently dysregulated in tumorigenesis through various mechanisms.
  • Dysfunctional miRNAs can promote cancer hallmarks like proliferation, metastasis, and angiogenesis, acting as oncogenes or tumor suppressors.
  • miRNAs are emerging as potential biomarkers for human cancers, requiring further validation.

Purpose of the Study:

  • To review the roles and mechanisms of miR-28-3p and miR-28-5p in human cancers.
  • To illustrate the potential of the miR-28 family as diagnostic biomarkers for cancer prognosis and early detection.

Main Methods:

  • Literature review of studies on microRNA function in cancer.
  • Analysis of the roles of specific microRNAs (miR-28-3p and miR-28-5p) in various malignancies.
  • Evaluation of the miR-28 family as potential cancer biomarkers.

Main Results:

  • hsa-miR-28 acts as an oncogene or tumor suppressor by modulating gene expression and signaling networks in malignancies.
  • MiR-28-5p and miR-28-3p, derived from the same precursor, play critical roles in diverse cancers.
  • The miR-28 family shows promise for cancer diagnosis and prognosis.

Conclusions:

  • Dysregulated microRNAs are implicated in cancer development and progression.
  • miR-28-3p and miR-28-5p are key players in various cancers with oncogenic or tumor-suppressive functions.
  • The miR-28 family holds significant potential as biomarkers for early cancer detection and patient prognosis.
Keywords:
CancerMiR-28Molecular functionOncogeneTumor suppressor

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