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Association Between Serum Trace Heavy Metals and Liver Function Among Adolescents
Daheng Yang1, Haobo Zhu, Hongjian Chen
1From the Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China (Yang), Department of Urology, Children's Hospital of Nanjing Medical University, Nanjing, China (Zhu), Department of Infection Disease, Children's Hospital of Nanjing Medical University, Nanjing, China (Chen), Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China (Dr Long).
Heavy metal exposure, specifically zinc in boys and mercury in girls, is linked to adolescent liver injury. This association may be influenced by cholesterol levels, highlighting the need for further research into environmental health impacts.
Area of Science:
- Environmental Health
- Adolescent Medicine
- Toxicology
Background:
- Metal exposure is a known risk factor for liver disease.
- Limited research exists on sex-specific effects on adolescent liver function.
Purpose of the Study:
- To investigate the association between serum heavy metals and liver function in adolescents.
- To explore potential sex differences in these associations.
Main Methods:
- Analysis of data from the National Health and Nutrition Examination Survey (2011-2016).
- Inclusion of 1143 adolescents aged 12-19 years.
- Measurement of serum heavy metals and liver enzymes (ALT, AST, GGT).
Main Results:
- A positive association was found between serum zinc and alanine aminotransferase (ALT) in boys.
- Serum mercury showed an association with increased ALT levels in girls.
- Total cholesterol partially mediated the relationship between serum zinc and ALT in boys.
Conclusions:
- Serum heavy metals are associated with an increased risk of liver injury in adolescents.
- Cholesterol may play a role in mediating these heavy metal-liver injury associations.
- Sex-specific effects warrant further investigation in adolescent environmental health studies.
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