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Corrigendum to: "Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function" [Ocul Surf 37 (2025) 201-215, https://doi.org/10.1016/j.jtos.2025.04.001].

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Apicobasal Polarity Protein PARD3 Plays an Essential Role in Human Corneal Epithelial Cells.

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Updated: Aug 8, 2025

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing
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Corneal epithelial development and homeostasis.

Shivalingappa K Swamynathan1, Sudha Swamynathan1

  • 1Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

Differentiation; Research in Biological Diversity
|March 4, 2023
PubMed
Summary

The corneal epithelium (CE) is vital for eye protection and function. Understanding its development and maintenance is key to treating related eye disorders.

Keywords:
CorneaDevelopmentEMTEpitheliumHomeostasisKLF4OSSNPlane of divisionPolarity

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Area of Science:

  • Ophthalmology
  • Developmental Biology
  • Cell Biology

Background:

  • The corneal epithelium (CE) is the eye's outermost layer, crucial for vision and protection.
  • Proper cell polarity and positioning are essential for CE function.
  • Disruptions in CE development or homeostasis can lead to eye disorders.

Approach:

  • This review synthesizes current research on CE development, maturation, and homeostasis.
  • It focuses on the role of transcription factors in regulating these processes.
  • The review aims to connect molecular events to the pathophysiology of CE disorders.

Key Points:

  • The CE is a self-renewing stratified squamous tissue.
  • Transcription factors play a critical role in CE development and maintenance.
  • Understanding CE biology is crucial for addressing vision impairment.

Conclusions:

  • Recent advances shed light on the molecular mechanisms governing CE development and homeostasis.
  • Further research into transcription factor networks can reveal therapeutic targets for corneal diseases.
  • This review provides a comprehensive overview for researchers and clinicians in the field.