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Related Experiment Video

Updated: Aug 8, 2025

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Broad-temperature-range mechanically tunable hydrogel microcapsules for controlled active release.

Hye-Seon Jeong1, Eunseo Kim2, Jong Pil Park3

  • 1School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea; Division of Cosmetic Science and Technology, Daegu Haany University, 1 Haanydaero, Gyeongsan, Gyeongbuk 38610, Republic of Korea.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|March 5, 2023
PubMed
Summary

We developed thermo-responsive microcapsules using PNIPAm-co-PEGDA hydrogels and an oil layer for controlled release of active compounds. Adjusting shell thickness and incorporating gold nanorods allows tunable and light-triggered release.

Keywords:
Droplet microfluidicsEncapsulationMicrocapsuleThermo-responsive releaseTriple emulsion

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Area of Science:

  • Materials Science
  • Biotechnology
  • Chemical Engineering

Background:

  • Developing controlled-release systems is crucial for drug delivery and material science.
  • Thermo-responsive polymers offer tunable properties for triggered release applications.
  • Microfluidics enables precise fabrication of complex microstructures like capsules.

Purpose of the Study:

  • To create tunable, thermo-responsive microcapsules for controlled release of hydrophilic actives.
  • To investigate the mechanism of temperature-induced release mediated by an interstitial oil layer.
  • To explore methods for enhancing release temperature and achieving spatiotemporal control.

Main Methods:

  • Fabrication of PNIPAm-co-PEGDA hydrogel shelled microcapsules using a microfluidic device and triple emulsion (W/O/W/O) method.
  • Utilizing a thin interstitial oil layer as a temperature-sensitive diffusion barrier.
  • Investigating the effect of crosslinker concentration and shell thickness on release properties.
  • Incorporating gold nanorods for near-infrared (NIR) light-triggered release.

Main Results:

  • Achieved tunable, temperature-responsive release of encapsulated actives.
  • Demonstrated that oil layer destabilization is driven by core expansion and shell deswelling.
  • Tuned release onset temperature up to 62°C by adjusting shell thickness.
  • Successfully achieved spatiotemporal release control using NIR light with gold nanorod-loaded capsules.

Conclusions:

  • PNIPAm-co-PEGDA hydrogel microcapsules with an oil layer provide a versatile platform for tunable thermo-responsive release.
  • The release mechanism is controllable by adjusting hydrogel composition, shell thickness, and external stimuli (temperature, light).
  • This technology holds promise for advanced drug delivery and controlled release applications.