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Published on: May 7, 2019
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Plasmapheresis in ABO incompatible kidney transplant
Hans Vrielink1, Kaatje le Poole1
1Sanquin Blood Supply, Unit of Transfusion Medicine, Plesmanlaan 125, 1066 CX Amsterdam, the Netherlands.
Summary
Kidney transplant success depends on HLA and ABO blood type compatibility. Double filtration apheresis can reduce antibodies in ABO-incompatible transplants from living donors, improving kidney survival.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- End-stage renal disease necessitates dialysis or kidney transplantation for survival.
- Kidney transplant success is influenced by human leukocyte antigen (HLA) and ABO blood group compatibility.
- ABO incompatibility poses a significant challenge in organ transplantation.
Purpose of the Study:
- To investigate the role of ABO blood type in kidney transplant outcomes.
- To evaluate the efficacy of double filtration apheresis in managing ABO-major incompatibility.
- To improve the survival of transplanted kidneys in ABO-incompatible scenarios.
Main Methods:
- Analysis of patient and donor ABO blood types.
- Application of double filtration apheresis prior to transplantation.
- Monitoring of anti-ABO antibody levels.
Main Results:
- ABO blood type is a critical factor for kidney transplant success.
- Double filtration apheresis effectively reduces anti-ABO antibodies.
- This reduction is crucial for ABO-major incompatible transplants from living donors.
Conclusions:
- ABO compatibility is essential for long-term kidney transplant survival.
- Double filtration apheresis is a viable strategy to mitigate risks associated with ABO-incompatible kidney transplantation.
- Optimizing ABO compatibility management enhances graft survival rates.
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