Bacteria as biofactory of pigments: Evolution beyond therapeutics and biotechnological advancements

Bacterial pigments are the wonder molecules of nature that have attracted the attention of industries in recent years. To date, various synthetic pigments have been in use in food, cosmetics, and textile industries that have not only shown a notoriously toxic nature but also posed threat to the ecosystem. Moreover, nutraceuticals, fisheries, and animal husbandry were highly dependent on plant sources for products that aid in disease prevention and improve stock health. In this context, the use of bacterial pigments as new-generation colorants, food fortifiers, and supplements can hold great prospects as low-cost, healthy, and eco-friendly alternatives. The majority of studies on these compounds were restricted to antimicrobial, antioxidant, and anticancer potentials to date. Each of these can be highly beneficial for the development of new-generation drugs, but their other potential niche in various industries that pose health and environmental risks needs to be explored. Recent advances in novel strategies of metabolic engineering, advancements in optimization tools for the fermentation process, and the design of appropriate delivery systems will greatly expand the market of bacterial pigments in industries. This review summarizes the current technologies for enhancing production, recovery, stability, and appreciable use of bacterial pigments in industries apart from therapeutics with proper financial aspects. The toxicity perspectives have been focused to emphasize that these wonder molecules are the need of the hour and their future prospects have been highlighted. Extensive literature has been studied to include the challenges of bacterial pigments from environmental and health risk perspectives.