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Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

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BK Polyomavirus-Induced Nephropathy in Native Kidney.

Ripudaman S Munjal¹, Jaskaran Munjal², Pulkit Gandhi^3,4

¹Nephrology, San Joaquin General Hospital, Stockton, USA.

|March 6, 2023

Summary

BK polyomavirus-associated nephropathy (BKN) is typically seen in kidney transplant recipients. This case highlights BKN occurring in a patient with a native kidney, emphasizing the need for broader diagnostic considerations.

Keywords:

acute kidney injury bk nephropathy bk polyomavirus chronic kidney disease dialysis immunosuppressed nephropathy

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Area of Science:

Nephrology
Virology
Immunology

Background:

BK polyomavirus establishes lifelong infections in renal and uroepithelial cells.
Reactivation in immunocompromised individuals can lead to BK polyomavirus-associated nephropathy (BKN).
BKN is primarily documented in kidney transplant patients.

Observation:

A 46-year-old male with HIV and B-cell lymphoma presented with unexplained worsening kidney function.
The patient was compliant with antiretroviral therapy (ART) and had undergone chemotherapy.
Kidney biopsy revealed findings consistent with BKN.

Findings:

The kidney biopsy confirmed BK polyomavirus-associated nephropathy (BKN).
This diagnosis was made in a patient with native kidneys, not transplanted ones.

Implications:

This case underscores that BKN can affect native kidneys, not just transplanted organs.
Clinicians should consider BKN in immunocompromised patients with native kidney dysfunction.
Further research may be needed to understand BKN in non-transplant native kidney settings.