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Three Patients With Chorea and Positive Voltage-Gated Potassium Channel Antibody: Is This the Link Between

Jacqueline Dulanto1, David Chu1, Pardis Saffari1

  • 1Internal Medicine, Adventist Health White Memorial, Los Angeles, USA.

Cureus
|March 6, 2023
PubMed

Insights

Movement disorders like chorea can occur after viral pandemics. Three COVID-19 patients developed chorea and voltage-gated potassium channel (VGKC) antibodies, suggesting a potential link and new treatment avenues.

Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Movement disorders, including chorea, have historically been documented following pandemics.
  • Delayed neurological complications are increasingly reported in the post-COVID-19 era, yet movement disorders are rare.
  • Voltage-gated potassium channel (VGKC) antibody-related movement disorders are infrequently documented.

Observation:

  • Three patients presented with neurological symptoms following COVID-19 infection.
  • These patients exhibited both chorea and the presence of VGKC antibodies.
  • This presentation suggests a potential association between COVID-19 and VGKC antibody-mediated movement disorders.

Findings:

  • The study identified a cohort of three patients with COVID-19-related chorea.
  • All three patients tested positive for VGKC antibodies.
  • This finding highlights a specific neurological complication linked to COVID-19.

Implications:

  • This research may elucidate the molecular mechanisms underlying von Economo disease.
  • A potential link between COVID-19 and VGKC antibody-related movement disorders is proposed.
  • Understanding this connection could inform novel immunomodulatory treatment strategies for post-COVID-19 neurological complications.

Keywords:
choreacovid-19postinfectiousvoltage-gated potassium channel antibodyvon economo disease

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