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The Burden of Uncontrolled Cardiovascular Risk Factors in Men With Prostate Cancer: A RADICAL-PC Analysis
Harry Klimis1, Jehonathan H Pinthus2, Nazanin Aghel1,3
1Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
JACC. Cardiooncology
|March 6, 2023
Summary
Men with prostate cancer (PC) often have uncontrolled cardiovascular risk factors. Over half had poor overall control, indicating a significant need for better cardiovascular risk management strategies in this population.
Area of Science:
- Oncology
- Cardiology
- Public Health
Background:
- Men with prostate cancer (PC) exhibit a higher incidence of cardiovascular disease (CVD).
- Understanding cardiovascular risk factor control is crucial for this patient group.
Purpose of the Study:
- To determine the prevalence and correlates of poor cardiovascular risk factor control in men with PC.
- To identify factors associated with suboptimal risk factor management.
Main Methods:
- A prospective study of 2,811 men with PC across multiple international sites.
- Defined poor overall risk factor control based on criteria for cholesterol, smoking, physical activity, blood pressure, and waist:hip ratio.
Main Results:
- Nearly all participants (99%) had at least one uncontrolled cardiovascular risk factor.
- 51% of men with PC demonstrated poor overall risk factor control.
- Factors associated with poor control included not taking statins, physical frailty, requiring blood pressure medication, and older age.
Conclusions:
- Poor control of modifiable cardiovascular risk factors is prevalent in men with PC.
- This highlights a significant gap in current care for cardiovascular risk management.
- There is a critical need for enhanced interventions to optimize cardiovascular health in men undergoing PC treatment.
Keywords:
ADT, androgen deprivation therapyBP, blood pressureCVD, cardiovascular diseaseECOG, Eastern Cooperative Oncology GroupGnRH, gonadotropin-releasing hormoneHDL, high-density lipoproteinHbA1c, glycosylated hemoglobinLDL, low-density lipoproteinPC, prostate cancerPHQ-9, Patient Health Questionnaire-9PSA, prostate-specific antigenandrogen deprivation therapycardiovascular disease preventioncardiovascular riskprospectiveprostate cancer
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