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Related Concept Videos

Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Renal Drug Excretion: Tubular Reabsorption01:25

Renal Drug Excretion: Tubular Reabsorption

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Tubular reabsorption, a process occurring post-glomerular filtration of drugs in the renal tubule, is a critical determinant of drug half-life. During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. This...
245
Renal Drug Excretion: Tubular Secretion01:28

Renal Drug Excretion: Tubular Secretion

243
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

30
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Dialysis01:27

Dialysis

413
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
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Related Experiment Video

Updated: Aug 8, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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[Plasma exchange in nephrology].

David A Jaques1

  • 1Service de néphrologie et hypertension, Hôpitaux universitaires de Genève, 1211 Genève 14.

Revue Medicale Suisse
|March 6, 2023
PubMed
Summary

Plasma exchange is a complex procedure in nephrology. This review covers key indications like anti-GBM disease, thrombotic microangiopathy, and kidney transplants, plus restricted use in ANCA vasculitis.

Area of Science:

  • Nephrology
  • Immunology
  • Hematology

Background:

  • Plasma exchange is a critical but challenging treatment in nephrology.
  • Understanding its indications is vital for effective patient management.
  • Recent evidence impacts established treatment protocols.

Approach:

  • This narrative review synthesizes current literature on therapeutic plasma exchange in nephrology.
  • It focuses on primary indications and evolving treatment guidelines.
  • Key diseases and clinical scenarios are discussed.

Key Points:

  • Major indications include anti-glomerular basement membrane disease and thrombotic microangiopathy.
  • Plasma exchange plays a role in various kidney transplant scenarios.
  • Recent evidence has led to restricted indications for plasma exchange in ANCA-associated vasculitis.

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Conclusions:

  • Mastering the indications for plasma exchange is essential for nephrologists.
  • The application of plasma exchange is evolving, particularly in autoimmune diseases.
  • This review provides a concise overview for clinical practice.