Related Experiment Video
Updated: Aug 8, 2025

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Design and development of orally disintegrating films: A platform based on hydroxypropyl methylcellulose and guar gum
Ana Flávia Freitas de Carvalho1, Vanessa Ferreira Caldeira2, Ana Paula Oliveira3
1Laboratory of Organic Chemistry, Federal University of the São Francisco Valley, Petrolina, Brazil; Center for Studies and Research in Biomaterials and Nanotechnology, Federal University of the São Francisco Valley, Petrolina, Brazil.
Abstract:
From a design of experiments (DOE) performed under four independent variables, with the filmogenicity conditions and shortest disintegration time as the answers, a new oral disintegrating film (ODF) based on hydroxypropyl methylcellulose (HPMC) and guar gum (GG) with the essential oil of Plectranthus amboinicus L. (EOPA) was developed. Sixteen formulations were tested for filmogenicity, homogeneity, and viability. The better selected ODF required 230.1 s for complete disintegration. The retention rate of the EOPA was quantified using the nuclear magnetic resonance hydrogen technique (H1 NMR), which identified the presence of 0.14 % carvacrol. The scanning electron microscopy showed a smooth and homogeneous surface with the presence of small white dots. Through the disk diffusion test, the EOPA was able to inhibit the growth of clinical strains of the Candida genus and gram-positive and gram-negative bacterial strains. This work opens new perspectives for the development of antimicrobial ODFS used in clinical practice.
More Related Videos
04:28Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals
Published on: March 23, 2016
04:09Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
Published on: December 13, 2024
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Drug Delivery: Enteral Route