Childhood maltreatment and social functioning in psychotic disorders: a systematic review protocol

Natalia E Fares-Otero1,2, Monique C Pfaltz3, Roberto Rodriguez-Jimenez4

  • 1Department of Psychiatry, Biomedical Research Institute, University Hospital 12 De Octubre (Imas12), Madrid, Spain.

Insights

Childhood maltreatment (CM) significantly impacts psychotic disorders (PD) and social functioning. This systematic review quantifies the CM-social functioning link in PD and explores influencing factors.

Area of Science:

  • Psychiatry
  • Psychology
  • Neuroscience

Background:

  • Childhood maltreatment (CM) is implicated in the development and progression of psychotic disorders (PD).
  • CM is linked to neurobiological and clinical factors affecting social functioning.
  • The direct association between CM and social functioning in PD requires clarification.

Purpose of the Study:

  • To systematically review and estimate the strength of the association between CM and social functioning in adults with PD.
  • To identify and summarize potential moderators and mediators of this association.
  • To provide a comprehensive understanding of CM's impact on social functioning in PD.

Main Methods:

  • Systematic literature search across major databases (PubMed, PsycInfo, Embase, Web of Science) and expert consultation.
  • Inclusion of studies reporting on CM (exposure) and social functioning (outcome) in adults with PD.
  • Data extraction and quality assessment using a modified Newcastle-Ottawa Scale by two independent reviewers.

Main Results:

  • Meta-analysis will be used to pool effect estimates of the CM-social functioning association.
  • Meta-regressions will analyze moderators including genetic factors, diagnosis type, illness duration, CM type, and age at exposure.
  • Qualitative examination of candidate moderators/mediators such as neurocognition, schemas, comorbidities, stress sensitivity, and attachment.

Conclusions:

  • This systematic review will quantify the association between childhood maltreatment and social functioning in individuals with psychotic disorders.
  • Findings will elucidate key moderators and mediators, informing targeted interventions.
  • The study aims to enhance understanding of CM's long-term impact on social recovery in PD.

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