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Published on: November 21, 2013
Childhood maltreatment and social functioning in psychotic disorders: a systematic review protocol
Natalia E Fares-Otero1,2, Monique C Pfaltz3, Roberto Rodriguez-Jimenez4
1Department of Psychiatry, Biomedical Research Institute, University Hospital 12 De Octubre (Imas12), Madrid, Spain.
Insights
Childhood maltreatment (CM) significantly impacts psychotic disorders (PD) and social functioning. This systematic review quantifies the CM-social functioning link in PD and explores influencing factors.
Area of Science:
- Psychiatry
- Psychology
- Neuroscience
Background:
- Childhood maltreatment (CM) is implicated in the development and progression of psychotic disorders (PD).
- CM is linked to neurobiological and clinical factors affecting social functioning.
- The direct association between CM and social functioning in PD requires clarification.
Purpose of the Study:
- To systematically review and estimate the strength of the association between CM and social functioning in adults with PD.
- To identify and summarize potential moderators and mediators of this association.
- To provide a comprehensive understanding of CM's impact on social functioning in PD.
Main Methods:
- Systematic literature search across major databases (PubMed, PsycInfo, Embase, Web of Science) and expert consultation.
- Inclusion of studies reporting on CM (exposure) and social functioning (outcome) in adults with PD.
- Data extraction and quality assessment using a modified Newcastle-Ottawa Scale by two independent reviewers.
Main Results:
- Meta-analysis will be used to pool effect estimates of the CM-social functioning association.
- Meta-regressions will analyze moderators including genetic factors, diagnosis type, illness duration, CM type, and age at exposure.
- Qualitative examination of candidate moderators/mediators such as neurocognition, schemas, comorbidities, stress sensitivity, and attachment.
Conclusions:
- This systematic review will quantify the association between childhood maltreatment and social functioning in individuals with psychotic disorders.
- Findings will elucidate key moderators and mediators, informing targeted interventions.
- The study aims to enhance understanding of CM's long-term impact on social recovery in PD.
Abstract:
Background: Childhood maltreatment (CM) is thought to play a key role in the etiology and course of psychotic disorders (PD). In addition, CM is related to neurobiological and clinical characteristics that can lead to poor social functioning. However, the extent to which CM and social functioning are directly associated in individuals with PD, is unclear. Therefore, we aim to systematically review the literature to provide an estimate on the strength of the association between CM and different domains of social functioning in PD and to summarize potential moderators and mediators of this association.Methods and analysis: To identify relevant studies, we will systematically search the following databases: Pubmed (Medline), PsycInfo, Embase, Web of Science (Core Collection), and Pilots (trauma), manually search reference lists and contact experts in the field. Studies will be included if they investigate and report on the association between CM (exposure) and social functioning (outcome) in adults with PD. Two independent reviewers will screen titles, abstracts and full texts according to eligibility criteria, perform data extraction and assess study quality according to a modified version of the Newcastle-Ottawa Scale.Analysis: Effect estimates will be pooled in a meta-analysis. Heterogeneity and publication bias will be assessed and the effects of potential moderators (genetic factors, type of diagnosis, duration of illness, type of CM and age at the time of CM exposure) will be analyzed using meta-regressions. Candidate moderators and mediators (neurocognition, cognitive schemas, comorbidities, stress sensitivity, attachment) will be also examined qualitatively.Ethics and dissemination: Because this review will make use of already published data, ethical approval will not be sought. This work has the potential to inform upcoming investigations on the association between the exposure to CM in PD and social functioning. PROSPERO registration number CRD42020175244.
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