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Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
Lucía Rodríguez-Pombo1, Laura Martínez-Castro1, Xiaoyan Xu2
1Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
International Journal of Pharmaceutics: X
|March 7, 2023
Summary
Rotary volumetric printing efficiently produces personalized 3D printed tablets (Printlets) simultaneously. This rapid 3D printing technology shows promise for the future of pharmaceutical manufacturing.
Area of Science:
- Pharmaceutical Technology
- Biomedical Engineering
- Materials Science
Background:
- 3D printing is shifting healthcare towards personalized treatments.
- High-throughput 3D printing is essential for clinical applications.
- Volumetric printing offers rapid object production within seconds.
Purpose of the Study:
- To investigate rotary volumetric printing for simultaneous production of personalized 3D printed tablets.
- To evaluate resin formulations for drug-loaded Printlets.
- To assess the speed and drug release characteristics of the printed tablets.
Main Methods:
- Rotary volumetric printing was employed to fabricate paracetamol-loaded Printlets.
- Six resin formulations containing paracetamol, PEGDA, PEG 300, and LAP were tested.
- Drug release profiles of the printed tablets were analyzed.
Main Results:
- Two paracetamol-loaded Printlets were successfully printed simultaneously in 12 to 32 seconds.
- The printed tablets demonstrated sustained drug release profiles.
- The study confirmed the feasibility of producing multiple tablets concurrently.
Conclusions:
- Rotary volumetric printing is a highly efficient method for manufacturing personalized medicines.
- This technology offers high speed and precision, suitable for pharmaceutical production.
- Rotary volumetric printing presents a promising alternative manufacturing technology for the pharmaceutical industry.
