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Updated: Aug 7, 2025

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
Catalytic Enantioselective [3+2] Cycloaddition of N-Metalated Azomethine Ylides
Sundaravel Vivek Kumar1, Patrick J Guiry1
1Centre for Synthesis and Chemical Biology (CSCB), School of Chemistry, University College Dublin (UCD) Belfield, Dublin 4, Ireland.
Abstract:
Asymmetric [3+2] cycloaddition reactions are fascinating and powerful methods for the synthesis of enantioenriched pyrrolidines up to four stereocentres. Pyrrolidines are important compounds for both biology and organocatalytic applications. This review summarizes the most recent advances in the enantioselective synthesis of pyrrolidines by [3+2] cycloadditions of azomethine ylides using metal catalysis. It has been organized by the type of metal catalysis used and further arranged by the complexity nature of dipolarophile. The presentation of each reaction type highlights their advantages and limitations.
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