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Depression Predicts Cardiac Cachexia in Heart Failure Patients
Samira M Moughrabi1, Samer I Habib2, Lorraine Evangelista3
1Associate Professor, California State University-Dominguez Hills, Carson, CA, USA.
Biological Research for Nursing
|March 7, 2023
Summary
Depression is a significant predictor of cardiac cachexia (CC) in heart failure (HF) patients. Early identification and management of depression may help prevent CC, improving patient outcomes.
Area of Science:
- Cardiology
- Psychiatry
- Internal Medicine
Background:
- Cardiac cachexia (CC) is a serious condition in heart failure (HF) patients, linked to higher mortality.
- The biological basis of CC is understood, but psychological factors remain understudied.
Purpose of the Study:
- To investigate if depression predicts the development of cardiac cachexia (CC) within six months in patients with chronic heart failure (HF).
Main Methods:
- 114 patients with chronic HF were assessed for depression using the PHQ-9.
- Body weight was monitored for six months to identify cachexia (≥6% unintentional weight loss).
- Regression analyses were used to determine the predictive value of depression on CC, controlling for other variables.
Main Results:
- Patients who developed cachexia had higher baseline depression scores and lower left ventricular ejection fraction (LVEF).
- Depression scores and LVEF were significant independent predictors of cardiac cachexia (CC), explaining 49% of the variance.
- When depression was dichotomized, both depression and LVEF predicted 52.6% of the variance in CC.
Conclusions:
- Depression is a significant predictor of cardiac cachexia (CC) in heart failure (HF) patients.
- Further research is needed to understand the psychological determinants of CC and inform treatment strategies.
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