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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Bone-Targeted Exosomes: Strategies and Applications.

Jian Wang^1,2,3, Xiaoqun Li⁴, Sicheng Wang^1,2

¹Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.

Advanced Healthcare Materials

|March 7, 2023

Summary

Modified exosomes show promise for treating bone diseases by targeting specific sites, improving efficacy, and reducing side effects. This review highlights their potential in clinical orthopedics.

Keywords:

bone regulation bone-related diseases bone-targeted strategies engineered modification exosomes

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Last Updated: Aug 7, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells

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Published on: June 30, 2023

Area of Science:

Biomedical Engineering
Regenerative Medicine
Nanotechnology

Background:

Bone-related diseases are a growing global health concern, particularly with an aging population.
Exosomes, natural cell-derived vesicles, offer therapeutic potential for bone diseases due to their biocompatibility and ability to penetrate biological barriers.
Current research lacks a comprehensive review of exosome-based bone-targeting strategies.

Purpose of the Study:

To review recent advancements in exosomes engineered for bone-targeting applications.
To explore strategies for modifying exosomes to enhance bone-targeting capabilities and therapeutic efficacy.
To summarize the therapeutic effects of bone-targeted exosomes for various bone-related diseases.

Main Methods:

Review of existing literature on exosome biogenesis and function in bone targeting.
Analysis of constructive strategies for modifying exosomes to improve bone-homing.
Evaluation of therapeutic outcomes reported for bone-targeted exosome applications in preclinical and clinical studies.

Main Results:

Modified exosomes demonstrate enhanced bone-targeting efficiency, potentially improving therapeutic outcomes.
Targeted delivery minimizes systemic side effects associated with conventional treatments.
Various modification strategies exist to optimize exosome bone-homing for specific disease contexts.

Conclusions:

Bone-targeted exosomes represent a promising therapeutic modality for bone-related diseases.
Strategic modification of exosomes is crucial for maximizing efficacy and minimizing off-target effects.
Further research and development are needed to fully realize the clinical translational potential of bone-targeted exosomes in orthopedics.