Related Experiment Video
Updated: May 8, 2026
07:42
A High-Throughput Platform for Culture and 3D Imaging of Organoids
Published on: October 14, 2022
Organoid research: new concepts and new technologies
Jin Zhang1,2,3,4,5, Yuezhou Wu6, Tianzhuo Shen1,2,3,4,5
1Institute of Translational Medicine, Shanghai University, No. 99 Shangda Road, Baoshan District, Shanghai 200444, China.
Burns & Trauma
|May 7, 2026
Summary
Organoids, 3D biomimetic systems, offer superior physiological relevance for research. Integrating organoid technology with AI and gene editing advances precision medicine, drug screening, and disease modeling.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Bioengineering
Background:
- Organoids are advanced 3D biomimetic systems derived from stem or somatic cells.
- They offer enhanced physiological relevance and predictive efficiency compared to 2D cultures and animal models.
- Organoids serve as crucial bridges between fundamental research and clinical applications.
Purpose of the Study:
- To review the integration of organoid technology with microfluidics, gene editing, and AI.
- To explore organoid applications in precision medicine, disease modeling, drug screening, and toxicology.
- To summarize recent advancements in organoid research and enabling technologies.
Main Methods:
- Review of interdisciplinary technologies including microfluidics, gene editing, and AI.
- Analysis of improvements in culture systems, materials, and multiomic analyses.
- Examination of organ-on-a-chip systems and organoid biobank construction.
Main Results:
- Organoid integration enhances applications in disease modeling, drug screening, and toxicology.
- Key technological developments improve culture systems, microfluidics, and analytical methods.
- Progress in organoid research supports regenerative medicine and personalized treatment strategies.
Conclusions:
- Despite challenges like standardization and clinical translation, interdisciplinary integration propels organoid development.
- Future organoid applications combined with AI and personalized medicine promise breakthroughs in disease mechanisms and precision treatment.
- Organoid technology is poised to significantly impact precision medicine and regenerative therapies.
