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Following the Dynamics of Structural Variants in Experimentally Evolved Populations
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Darwinian evolution as a dynamical principle.

Charles D Kocher1,2, Ken A Dill1,2,3

  • 1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794.

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PubMed
Summary
This summary is machine-generated.

Darwinian evolution (DE) requires multiple organisms to persist and overcome challenges. Resource dynamics, not just mutation, drive DE, necessitating separate steps for variation and selection.

Keywords:
Darwinian evolutioncompetitive exclusiondriven nonequilibriumsurvival of the fittest

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Area of Science:

  • Evolutionary biology
  • Computational modeling
  • Dynamical processes

Background:

  • Darwinian evolution (DE) is a fundamental biological process driving adaptation.
  • DE exhibits unique characteristics, including being antithermodynamic and persisting for billions of years.
  • The concept of fitness in DE can be challenging to explain mechanistically.

Purpose of the Study:

  • To investigate the core mechanisms driving Darwinian evolution.
  • To understand the conditions necessary for the long-term persistence of DE.
  • To explore the relationship between resource dynamics, mutation, and fitness advancement.

Main Methods:

  • Development of a computational model, the Darwinian Evolution Machine (DEM).
  • Simulation of resource-driven duplication and competition within a search/compete/choose cycle.
  • Analysis of factors influencing DE persistence and fitness landscape traversal.

Main Results:

  • Multiorganism coexistence is essential for DE's long-term persistence and ability to cross fitness valleys.
  • Resource dynamics, including "booms and busts," are significant drivers of DE, alongside mutational changes.
  • A mechanistic separation between variation and selection steps is crucial for fitness ratcheting.

Conclusions:

  • DE necessitates multiorganism interactions for sustained adaptation and overcoming evolutionary hurdles.
  • The interplay of resource availability and organismal competition is a key driver of evolutionary trajectories.
  • The distinct roles of DNA (variation) and proteins (selection) in biology may reflect the requirement for separate variation and selection mechanisms in DE.