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A Case of Neonatal Myeloid Sarcoma
Halie Burdick1, Jordan Bormann1, KayeLyn Wagner2
1University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
A rare neonatal myeloid sarcoma (MS) skin presentation preceded acute myeloid leukemia (AML) by seven days. This case highlights MS as a potential early indicator for prompt AML diagnosis and treatment.
Area of Science:
- Hematology
- Pediatric Oncology
- Dermatology
Background:
- Neonatal myeloid sarcoma (MS) is a rare malignancy.
- Early diagnosis of MS can be challenging.
- MS can precede or coincide with acute myeloid leukemia (AML).
Observation:
- A case of cutaneous neonatal myeloid sarcoma (MS) is presented.
- The infant was diagnosed with acute myeloid leukemia (AML) seven days after MS diagnosis.
- Unusual cytogenetic findings included a triple copy of KAT6A abnormality and a complex 8;14;22 translocation.
Findings:
- Cutaneous MS can be an initial presenting sign of underlying AML.
- The specific genetic abnormalities identified (KAT6A, 8;14;22 translocation) are noteworthy.
- The temporal relationship between MS and AML in this case is significant.
Implications:
- Diagnosis of cutaneous MS warrants thorough evaluation for systemic AML.
- Prompt recognition and treatment of neonatal AML can improve outcomes.
- This case underscores the importance of considering hematologic malignancies in neonatal skin lesions.
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