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Updated: Aug 7, 2025

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
[Coordinated management of arterial hypertension]
Loïc Dällenbach1, Lorenzo Pucci1, Valérie Duchatelle2
1Service de cardiologie, Centre hospitalier du Valais romand, 1951 Sion.
Insights
Arterial hypertension control is insufficient despite available treatments. Renal denervation shows promise for lowering blood pressure, potentially improving future hypertension management strategies.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Context:
- Arterial hypertension management remains challenging despite therapeutic advancements and poly-pill options.
- Resistant hypertension often requires multidisciplinary care involving internal medicine, nephrology, and cardiology specialists.
- Current treatment guidelines recommend ACEI/ARA2, thiazide-like diuretics, and calcium channel blockers as reference triple therapy.
Purpose:
- To review the current landscape of arterial hypertension control.
- To highlight the emerging role of renal denervation in managing resistant hypertension.
- To discuss the potential integration of renal denervation into future clinical guidelines.
Summary:
- Despite numerous treatments, hypertension control is inadequate, necessitating multidisciplinary approaches.
- Resistant hypertension cases often fail to respond to standard triple therapy (ACEI/ARA2, thiazide-like diuretic, CCB).
- Recent studies indicate renal denervation effectively lowers blood pressure, offering a new therapeutic avenue.
Impact:
- Renal denervation may become a key strategy for improving blood pressure control in resistant hypertension.
- The integration of renal denervation into guidelines could enhance treatment options and patient outcomes.
- This technique has the potential to significantly advance the management of arterial hypertension globally.
Abstract:
Despite major therapeutic progress and the numerous poly-pill combinations available on the market today, the control of arterial hypertension remains widely insufficient. A multidisciplinary management putting together internal medicine, nephrology and cardiology specialist offers the best chances for patients to achieve their blood pressure goals, especially when suffering from resistant hypertension despite adequate prescription of the reference tri therapy: ACEI/ARA2 combined with a thiazide-like diuretic and calcium channel blocker. Recent studies and randomized trials from the last five years shed a new light on the value of renal denervation and its efficacy on lowering blood pressure. This will probably lead to the integration of this technique in the next guidelines and improve its adoption over the next years.
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