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Clinical correlation of 2D shear wave elastography findings in children with type 1 diabetes mellitus without

Hanife Gülden Düzkalır1, Ömer Aydıner1, Elif Söbü2

  • 1Department of Radiology, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Türkiye.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|March 8, 2023
PubMed

Insights

Two-dimensional shear wave elastography (2D SWE) did not reveal differences in thyroid gland elasticity in children with type 1 diabetes mellitus (T1DM) without thyroid autoimmunity. This suggests 2D SWE may aid in early detection of thyroid issues in T1DM patients before autoimmunity develops.

Area of Science:

  • Pediatric Endocrinology
  • Medical Imaging
  • Rheumatology

Background:

  • Type 1 diabetes mellitus (T1DM) can affect thyroid function.
  • Early detection of thyroid involvement in T1DM is crucial.
  • Thyroid autoimmunity (AIT) is common in T1DM patients.

Purpose of the Study:

  • To evaluate thyroid gland elasticity using 2D shear wave sonoelastography (SWE) in children with T1DM.
  • To assess T1DM patients without AIT and normal gray-scale ultrasound findings.
  • To identify potential early markers of thyroid involvement in T1DM.

Main Methods:

  • The study included 46 T1DM patients and 46 healthy controls.
  • Thyroid gland mean elasticity was measured using 2D SWE (in kPa).
  • Elasticity values were correlated with clinical and laboratory parameters.

Main Results:

  • No significant difference in thyroid gland elasticity was found between T1DM patients and controls (p=0.15).
  • 2D SWE values showed no significant correlation with age at diagnosis, thyroid hormones, or diabetes control (HbA1c).
  • No correlation was observed with specific autoantibodies (anti-thyroglobulin, anti-tissue peroxidase).

Conclusions:

  • Thyroid gland elasticity is not significantly altered in T1DM children without AIT.
  • 2D SWE may serve as a valuable tool for early detection of thyroid affections in T1DM prior to AIT development.
  • Further longitudinal studies are recommended to confirm the utility of 2D SWE in T1DM thyroid monitoring.
Abstract

Keywords:
childrensonoelastographythyroidtissue elasticity imagingtype 1 diabetes mellitus

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