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[Stiff-tail or midpiece syndrome].

G Schieferstein¹, H Wolburg, W Adam

¹Abt. Dermatologie II, Universitäts-Hautklinik Tübingen.

|January 1, 1987

Summary

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A rare sperm defect caused severe male infertility in a 40-year-old man. Electron microscopy revealed disorganized mitochondria and stiff spermatozoa, impacting motility.

Area of Science:

Reproductive biology
Human genetics
Spermatology

Background:

Investigating the causes of unexplained male infertility.
Examining rare congenital sperm malformations.
Understanding the role of sperm structure in fertility.

Observation:

A 40-year-old man presented with 17 years of unexplained infertility.
Sperm analysis revealed a rare malformation with stiff spermatozoa and reduced motility.
Electron microscopy was utilized for detailed ultrastructural examination.

Findings:

Spermatozoa exhibited complete stiffness or severely decreased motility localized to the flagellar tip.
Ultrastructural analysis showed elongated and disorganized mitochondrial sheaths.
Frequent presence of cytoplasmic droplets was noted in the spermatozoa.

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Implications:

This case highlights a rare sperm defect potentially causing severe male infertility.
Understanding such malformations is crucial for diagnosing and managing infertility.
Further research into mitochondrial sheath organization and its impact on sperm motility is warranted.