Related Experiment Video
Updated: Aug 7, 2026

10:10
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
Central nervous system complications after 6000 retrobulbar blocks
J M Nicoll1, P A Acharya, K Ahlen
1Department of Anesthesia, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Anesthesia and Analgesia
|December 1, 1987
Summary
Retrobulbar anesthesia for ophthalmic surgery can lead to central nervous system complications in 1 in 375 patients. While rare, these serious adverse events necessitate closely monitored anesthesia care.
Area of Science:
- Anesthesiology
- Ophthalmology
- Neurology
Background:
- Retrobulbar anesthesia is a common technique for ophthalmic surgery.
- Direct spread of local anesthetic to the central nervous system (CNS) is a potential complication.
Purpose of the Study:
- To investigate the incidence and spectrum of CNS complications following retrobulbar anesthesia.
- To assess the predictability and severity of these adverse events.
Main Methods:
- Retrospective analysis of 6,000 consecutive patients undergoing retrobulbar anesthesia.
- Documentation of all observed neurological and systemic signs and symptoms post-injection.
Main Results:
- Sixteen patients (1 in 375) experienced CNS complications.
- Symptoms ranged from mild drowsiness to severe events like respiratory depression, seizures, and cardiopulmonary arrest.
- Onset time was variable (average 8 minutes), and severity was unrelated to anesthetic dose.
- Life-threatening complications occurred rarely (1 in 750) but were unpredictable.
Conclusions:
- Direct CNS spread of local anesthetics during retrobulbar anesthesia is an infrequent but serious risk.
- The unpredictable nature and potential severity underscore the need for vigilant monitoring.
- Continuous anesthesia care is crucial for patients receiving retrobulbar anesthesia.
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

