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Lipoatrophic panniculitis: a possible autoimmune inflammatory disease of fat. Report of three cases
J K Billings1, S S Milgraum, A K Gupta
1Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
Abstract:
We observed three children with a clinically similar presentation of erythematous nodules that expanded centrifugally leaving lipoatrophy. Areas of lipoatrophy coalesced, resulting in clinical pictures similar to partial or total lipodystrophy. Histologic study revealed a lobular panniculitis with a mixed infiltrate of lymphocytes and mononuclear phagocytes. Of these three children, one had insulin-dependent diabetes mellitus and Hashimoto's thyroiditis, one developed juvenile rheumatoid arthritis, and the third developed insulin-dependent diabetes mellitus, suggesting that the pathogenic mechanism may be an expression of autoimmunity.
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