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Updated: Aug 7, 2025
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Image-guided radiofrequency ablation for adrenal metastatic tumors: a systematic review and meta-analysis
Wei Liu1, Ying Zhang2, Yu-Fei Fu2
1Department of Oncology, Xuzhou Central Hospital, Xuzhou, P.R. China.
Purpose:
To evaluate the safety and clinical efficacy of image-guided radiofrequency ablation (RFA) in patients exhibiting adrenal metastatic tumors (AMTs).
Methods:
The PubMed, Web of Science, and Wanfang databases were searched for relevant studies published as of November 2022, and study results were pooled for subsequent analysis. The endpoints of this meta-analysis included primary and secondary technical success, local hemorrhage, pneumothorax, hypertensive crisis, local recurrence, and 1- and 3-year overall survival (OS) rates.
Results:
This analysis incorporated 11 studies enrolling 351 patients that underwent RFA treatment for 373 AMTs. The pooled primary and secondary technical success, local hemorrhage, pneumothorax, hypertensive crisis, local recurrence, and 1- and 3-year OS rates in these patients were 84%, 91%, 4%, 6%, 7%, 19%, 82%, and 46%, respectively. The 1-year OS (I = 75.2%, p = 0.003) and 3-year OS (I = 81.4%, p = 0.001) endpoints were subject to significant heterogeneity. Subgroup analyses suggested that primary technical success rates were < 80% in patients with tumors exhibiting a mean diameter ≥ 4 cm. Guidance type and tumor size had no impact on a hypertensive crisis or local recurrence rates.
Conclusions:
These data indicate that image-guided RFA represents a safe and effective means of treating AMTs.
Insights
Image-guided radiofrequency ablation (RFA) is a safe and effective treatment for adrenal metastatic tumors (AMTs). This meta-analysis found high technical success rates and acceptable complication rates, supporting RFA for AMTs.
Area of Science:
- Oncology
- Interventional Radiology
- Surgical Oncology
Background:
- Adrenal metastatic tumors (AMTs) pose a significant clinical challenge.
- Effective treatment options for AMTs are crucial for improving patient outcomes.
Conclusions:
- Image-guided radiofrequency ablation (RFA) is a safe and effective therapeutic modality for adrenal metastatic tumors (AMTs).
- Lower primary technical success rates (<80%) were noted for tumors with a mean diameter ≥4 cm.
- Guidance type and tumor size did not significantly impact hypertensive crisis or local recurrence rates.
