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High lipoprotein(a) levels and mitral valve disease: A systematic review

Walter Masson1, Leandro Barbagelata1, Pablo Oberti1

  • 1Servicio de Cardiología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|March 8, 2023
PubMed

Insights

Lipoprotein(a) [Lp(a)] may be linked to mitral valve calcification, but its role in mitral valve dysfunction is unclear. Further research is needed to confirm these associations in heart disease.

Area of Science:

  • Cardiology
  • Genetics
  • Epidemiology

Background:

  • Lipoprotein(a) [Lp(a)] is a recognized risk factor for atherosclerotic cardiovascular diseases.
  • Previous research on Lp(a) and mitral valve disease is limited and yields conflicting results.
  • Understanding the Lp(a) and mitral valve disease link is crucial for cardiovascular risk assessment.

Conclusions:

  • The association between Lp(a) and mitral valve calcification appears robust, aligning with findings in aortic valve disease.
  • The role of Lp(a) in mitral valve dysfunction requires further investigation.
  • Additional research is necessary to elucidate the complex relationship between Lp(a) and mitral valve disease.
Abstract

Keywords:
Lipoprotein(a)Mitral valve calcificationMitral valve diseaseSystematic review

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