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BIN1 in cancer: biomarker and therapeutic target

Si-Yu Chen1, Jin-Long Cao1, Kun-Peng Li1

  • 1Department of Urology, The Second Hospital of Lanzhou University, Lanzhou, China.

Journal of Cancer Research and Clinical Oncology
|March 8, 2023
PubMed
Abstract

Insights

Bridging integrator 1 (BIN1) acts as a tumor suppressor, regulating cancer progression. Its differential expression suggests BIN1 is a potential prognostic marker for human cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Bridging integrator 1 (BIN1) functions as a pro-apoptotic tumor suppressor, inhibiting MYC transcription factors.
  • BIN1 plays roles in endocytosis, membrane cycling, cytoskeletal regulation, DNA repair, cell-cycle arrest, and apoptosis.
  • BIN1 expression is linked to cancer, Alzheimer's disease, myopathy, heart failure, and inflammation.

Purpose of the Study:

  • To review the pathological mechanisms of BIN1 in human cancer development.
  • To evaluate BIN1's potential as a prognostic marker and therapeutic target in cancers.
  • Focus on differential expression of BIN1 in normal versus cancerous tissues.

Main Methods:

  • Literature review of recent findings on BIN1's molecular, cellular, and physiological roles.
  • Analysis of BIN1's involvement in cancer progression and the tumor microenvironment.
  • Examination of BIN1's expression patterns in various human cancers.

Main Results:

  • BIN1 is typically expressed in normal differentiated tissues but undetectable in metastatic cancers.
  • BIN1 acts as a tumor suppressor, influencing cancer development through various signaling pathways.
  • BIN1's distinct expression profile supports its role in tumor progression.

Conclusions:

  • BIN1 is a crucial tumor suppressor regulating cancer development and the tumor microenvironment.
  • BIN1's differential expression makes it a feasible marker for early cancer diagnosis and prognosis.
Keywords:
ApoptosisBridging integrator 1 (BIN1)CancerChemoresistancec-MYC

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