Polysaccharide-Based Stimulus-Responsive Nanomedicines for Combination Cancer Immunotherapy

Area of Science:

• Biomaterials Science
• Nanomedicine
• Cancer Research

Background:

• Cancer immunotherapy shows promise but faces challenges including side effects, complex tumor microenvironments, and low tumor immunogenicity.
• Combination immunotherapy strategies significantly enhance antitumor efficacy but face codelivery challenges.
• Stimulus-responsive nanodelivery systems offer controlled drug delivery and precise release at the tumor site.

Purpose of the Study:

• To review the antitumor activity of polysaccharides in combination cancer immunotherapy.
• To discuss the progress of polysaccharide-based stimulus-responsive nanomedicines for combination cancer immunotherapy.
• To highlight the construction, targeted delivery, drug release, and enhanced antitumor effects of these nanomedicines.

Main Methods:

• Literature review of polysaccharide applications in cancer immunotherapy.
• Analysis of polysaccharide-based stimulus-responsive nanomedicines.
• Discussion of combination strategies including chemotherapy, photodynamic therapy, and photothermal therapy.

Main Results:

• Polysaccharides are versatile biomaterials for developing stimulus-responsive nanomedicines.
• These nanomedicines facilitate codelivery of therapeutic agents for enhanced combination cancer immunotherapy.
• Focus on nanomedicine construction, targeted delivery, controlled release, and improved antitumor outcomes.

Conclusions:

• Polysaccharide-based stimulus-responsive nanomedicines represent a significant advancement in combination cancer immunotherapy.
• Further research is needed to address limitations and explore application prospects.
• This approach holds potential for more effective and targeted cancer treatment.