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[First malaria vaccine recommended by WHO]
Wendé-Waoga Guillaume Zango1, Marie-Fleur Durieux2, Jean-François Faucher3
1Faculté de pharmacie de Limoges, Limoges, France.
La Revue Du Praticien
|March 9, 2023
Summary
The first WHO-recommended malaria vaccine, RTS,S/AS01, offers moderate protection against Plasmodium falciparum malaria. Its recent recommendation for widespread use in children is a significant step, though its adoption timeline remains uncertain.
Area of Science:
- Immunology
- Vaccinology
- Infectious Diseases
Context:
- The World Health Organization (WHO) recommended the RTS,S/AS01 malaria vaccine in October 2021.
- This marks a significant milestone as the first malaria vaccine endorsed for widespread use.
- The vaccine targets Plasmodium falciparum malaria, a major global health concern.
Purpose:
- To summarize the development and characteristics of the RTS,S/AS01 malaria vaccine.
- To discuss its efficacy, mechanism of action, and the implications of the WHO recommendation.
- To highlight the ongoing need for more effective malaria interventions.
Summary:
- RTS,S/AS01 is a recombinant protein vaccine developed over decades, inducing humoral and cell-mediated immune responses against the circumsporozoite protein of Plasmodium falciparum.
- It provides moderate efficacy against malaria, serving as an additional tool for disease control and elimination efforts.
- The WHO's recommendation for its use in children in malaria-endemic areas brings hope but also raises concerns.
Impact:
- The recommendation of RTS,S/AS01 represents a crucial advancement in the fight against malaria, particularly in vulnerable populations.
- While not a complete solution, it offers a new avenue for malaria prevention and control.
- Further research is anticipated to yield more effective malaria vaccines in the future, but the adoption and impact of RTS,S/AS01 are key considerations.
Keywords:
Malaria
