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Crosstalk between circRNAs and the PI3K/AKT and/or MEK/ERK signaling pathways in digestive tract malignancy

Chao Wu1,2, Xing Huang2, Mao Li2

  • 1Department of General Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Future Oncology (London, England)
|March 9, 2023
PubMed

Insights

Circular RNAs (circRNAs) regulate gene expression by binding to microRNAs (miRNAs). Their tissue specificity offers potential for diagnosing and treating digestive tract cancers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are formed by back-splicing, possessing a stable, covalently closed structure.
  • circRNAs regulate gene expression via binding to microRNAs (miRNAs) at miRNA response elements.
  • circRNA biogenesis is controlled by cell-specific and gene-specific mechanisms, leading to tissue and tumor specificity.

Purpose of the Study:

  • To review the classification and functions of circRNAs.
  • To summarize the role of circRNAs in regulating PI3K/AKT and MEK/ERK signaling pathways.
  • To highlight the potential of circRNAs in digestive tract malignancies.

Main Methods:

  • Literature review of current research on circRNAs.
  • Analysis of circRNA biogenesis and regulatory mechanisms.
  • Examination of circRNA involvement in key signaling pathways in cancer.

Main Results:

  • circRNAs exhibit high stability and tissue specificity.
  • Specific circRNAs are implicated in the regulation of PI3K/AKT and MEK/ERK pathways.
  • circRNAs show promise as biomarkers for early diagnosis and survival prediction.

Conclusions:

  • circRNAs are crucial regulators of gene expression with potential diagnostic and therapeutic applications.
  • The stability and specificity of circRNAs make them valuable for precision medicine in digestive tract cancers.
  • Further research into circRNA functions can advance understanding and treatment of these malignancies.
Keywords:
MARK/ERK signaling pathwaysPI3K/AKT signaling pathwayscircRNAsdigestive tract malignancy

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