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Type I Interferon Signature in NOTCH1-Related Leukoencephalopathy

Francesco Nicita1, Lorena Travaglini1, Valentina Matteo2

  • 1Genetics and Rare Diseases Research Division, Unit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, Bambino Gesù Children's Hospital, Scientific Institute for Research and Health Care, Rome, Italy.

Annals of Neurology
|March 9, 2023
PubMed
Abstract

No abstract available in PubMed .

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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