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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Laser-responsive sequential delivery of multiple antimicrobials using nanocomposite hydrogels.

Meera Patel1,2, Alexander L Corbett1,2, Aarushi Vardhan1

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Antibiotic resistance necessitates advanced drug delivery methods.
  • Controlled release of antimicrobials can mitigate adverse effects and enhance efficacy.
  • Nanocomposite hydrogels offer potential for sophisticated therapeutic delivery.

Purpose of the Study:

  • To develop a nanocomposite hydrogel for precise, sequential antimicrobial and adjuvant delivery.
  • To utilize photothermal properties of polydopamine nanoparticles and liposome transitions for triggered release.
  • To demonstrate the prevention of bacterial growth through controlled drug release.

Main Methods:

  • Fabrication of a nanocomposite hydrogel incorporating polydopamine nanoparticles and liposomes.
  • Loading of an antibiotic and its adjuvant into the hydrogel system.
  • Application of near-infrared (NIR) laser irradiation to trigger sequential release.
  • Assessment of bacterial growth inhibition post-treatment.

Main Results:

  • The nanocomposite hydrogel demonstrated controlled, sequential release of the antibiotic and adjuvant upon NIR laser stimulation.
  • Polydopamine nanoparticles facilitated photothermal conversion for precise temperature control.
  • Liposome transition temperatures were exploited for distinct release phases.
  • Effective prevention of bacterial growth was observed with the sequential delivery system.

Conclusions:

  • A novel nanocomposite hydrogel system enables precise, NIR-triggered sequential delivery of antimicrobials and adjuvants.
  • This approach offers a promising strategy for combating bacterial infections while minimizing side effects.
  • The developed system represents a significant advancement in controlled drug delivery for infectious diseases.