Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Distributed Loads: Problem Solving01:21

Distributed Loads: Problem Solving

687
Beams are structural elements commonly employed in engineering applications requiring different load-carrying capacities. The first step in analyzing a beam under a distributed load is to simplify the problem by dividing the load into smaller regions, which allows one to consider each region separately and calculate the magnitude of the equivalent resultant load acting on each portion of the beam. The magnitude of the equivalent resultant load for each region can be determined by calculating...
687
Distribution Reliability and Automation01:25

Distribution Reliability and Automation

141
Distribution reliability in electrical power systems is critical for ensuring an uninterrupted power supply to consumers at minimal cost. According to IEEE Standard Terms, reliability is the probability that a device will function without failure over a specified time period or amount of usage. For electric power distribution, this translates to maintaining continuous power supply and addressing customer concerns over power outages. Several indices, as defined by IEEE Standard 1366-2012, are...
141
Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview01:25

Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

103
Drug administration can occur through various routes, each of which may result in a different process of elimination. This process is often mixed with nonlinear and linear processes. It's important to understand that a single drug can be metabolized into different metabolites through parallel processes.
For instance, consider the metabolism of sodium salicylate. This compound is metabolized into two distinct substances: a glucuronide and a glycine conjugate. The rate of conjugation depends...
103
Drug Distribution: Volume of Distribution01:25

Drug Distribution: Volume of Distribution

5.3K
The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.
5.3K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

620
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
620
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

104
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
104

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy.

Journal of translational medicine·2025
Same author

Hypoxia-Induced <i>VGF</i> Promotes Cell Migration and Invasion in Prostate Cancer via the PI3K/Akt Axis.

Frontiers in bioscience (Landmark edition)·2025
Same author

lncRNA MAGI2-AS3 suppresses castration-resistant prostate cancer proliferation and migration via the miR-106a-5p/RAB31 axis.

Genomics·2023
Same author

Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond.

Diabetes, metabolic syndrome and obesity : targets and therapy·2022
Same author

HepaCAM‑PIK3CA axis regulates the reprogramming of glutamine metabolism to inhibit prostate cancer cell proliferation.

International journal of oncology·2022
Same author

Panobinostat reverses HepaCAM gene expression and suppresses proliferation by increasing histone acetylation in prostate cancer.

Gene·2021
Same journal

Characterization of genomic diversity in bacteriophages infecting Rhodococcus.

PloS one·2026
Same journal

Effectiveness of the Responding to Experienced and Anticipated Discrimination (READ) training on reducing stigma for medical students in Tunisia.

PloS one·2026
Same journal

Cell-cell junction gene signatures as subtype-specific prognostic biomarkers in breast cancer.

PloS one·2026
Same journal

GC-MS based tentative identification of γ-sitosterol from Brassica nigra seeds and evaluation of its anticancer potential: An integrated in vitro and in silico study.

PloS one·2026
Same journal

Ad-based social media interventions increase belief accuracy and generate pro-social opinions among non-news readers.

PloS one·2026
Same journal

Negotiating knowledge: The role of network hedging in the production of high-impact science.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Aug 7, 2025

Spotlighting Customers' Visual Attention at the Stock, Shelf and Store Levels with the 3S Model
06:30

Spotlighting Customers' Visual Attention at the Stock, Shelf and Store Levels with the 3S Model

Published on: May 24, 2019

5.3K

Multi-store collaborative delivery optimization based on Top-K order-split.

Yanju Zhang1, Liping Ou1, Jiaxu Liu2

  • 1School of Business Administration, Liaoning Technical University, Huludao, Liaoning, China.

Plos One
|March 9, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces Multi-Store Collaborative Delivery Optimization (MCDO) for retailers using stores as warehouses. A novel TKILS algorithm efficiently optimizes order splitting and delivery routes to minimize fulfillment costs.

More Related Videos

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'
10:31

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

11.2K
Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.7K

Related Experiment Videos

Last Updated: Aug 7, 2025

Spotlighting Customers' Visual Attention at the Stock, Shelf and Store Levels with the 3S Model
06:30

Spotlighting Customers' Visual Attention at the Stock, Shelf and Store Levels with the 3S Model

Published on: May 24, 2019

5.3K
A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'
10:31

A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'

Published on: February 10, 2017

11.2K
Operation of the Collaborative Composite Manufacturing CCM System
10:09

Operation of the Collaborative Composite Manufacturing CCM System

Published on: October 1, 2019

6.7K

Area of Science:

  • Operations Research
  • Supply Chain Management
  • E-commerce Logistics

Background:

  • Traditional retail order fulfillment often overlooks physical stores as key logistical hubs.
  • The rise of new retailing necessitates models integrating online orders with in-store fulfillment capabilities.
  • Existing research inadequately addresses joint optimization of order splitting and delivery from physical stores.

Purpose of the Study:

  • To address the gap in optimizing online order fulfillment for traditional retailers using physical stores.
  • To introduce the Multi-Store Collaborative Delivery Optimization (MCDO) problem.
  • To develop an efficient algorithm for minimizing order fulfillment costs in a multi-store environment.

Main Methods:

  • Development of the Multi-Store Collaborative Delivery Optimization (MCDO) problem formulation.
  • Integration of Top-K breadth-first search and local search into a hybrid heuristic algorithm (TKILS).
  • Optimization of search efficiency by controlling sub-orders and improving initial solutions with a greedy cost function.

Main Results:

  • The proposed TKILS algorithm effectively optimizes both order splitting and delivery routing.
  • Experiments demonstrate the algorithm's ability to minimize overall order fulfillment costs.
  • Validation of the algorithm's effectiveness and applicability on synthetic and real-world datasets.

Conclusions:

  • The MCDO problem and TKILS algorithm offer a novel solution for retailers leveraging physical stores for online order fulfillment.
  • The hybrid heuristic approach significantly enhances the efficiency and effectiveness of order fulfillment processes.
  • This research provides a practical and scalable method for optimizing multi-store collaborative deliveries in the new retail landscape.