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Related Experiment Video

Updated: Aug 7, 2025

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Next-generation biomaterials for dental pulp tissue immunomodulation.

Renan Dal-Fabbro¹, W Benton Swanson², Leticia C Capalbo¹

¹Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

Dental Materials : Official Publication of the Academy of Dental Materials

|March 9, 2023

Summary

Regenerative dentistry utilizes immunomodulatory biomaterials to heal damaged dental pulp, offering a promising alternative to root canal therapy for improved long-term tooth outcomes.

Keywords:

Biomaterials Dental pulp Immunomodulation Regeneration Tissue engineering Tissue scaffolds

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Last Updated: Aug 7, 2025

Accessing the Cytotoxicity and Cell Response to Biomaterials

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Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

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Published on: May 5, 2023

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

Area of Science:

Biomaterials Science
Regenerative Medicine
Immunology

Background:

Current root canal therapy involves removing and filling damaged dental pulp with inert materials.
Regenerative approaches aim to heal native tooth structures and improve outcomes for necrotic teeth.

Purpose of the Study:

To review advancements in dental pulp tissue engineering.
To explore the synergy between immunomodulatory biomaterials and tissue engineering for next-generation dental technologies.

Main Methods:

Overview of dental pulp inflammation and immune responses.
Discussion of recent advances in treating oral inflammatory diseases with immunomodulatory biomaterials.
Highlighting surface and content modifications of biomaterials for immunomodulation.

Main Results:

Recent progress in developing biomaterials that leverage the immune system for regeneration.
Biomaterials effectively modulating dental pulp cells show clinical promise.
These approaches may enhance care compared to traditional root canal therapy.

Conclusions:

Biomaterials harnessing the host immune system are advancing regenerative dentistry.
Targeted immunomodulation of dental pulp cells offers a new paradigm for tooth repair.
This synergy holds potential for superior clinical outcomes in endodontics.