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Optic radiations representing different eccentricities age differently.

John Kruper1,2, Noah C Benson2, Sendy Caffarra3,4

  • 1Department of Psychology, University of Washington, Seattle, Washington, USA.

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Summary
This summary is machine-generated.

Neural pathways in the optic radiations (OR) show distinct properties based on visual field. Aging affects these pathways, with foveal regions degrading faster than peripheral ones.

Keywords:
DKIU.K. biobankagingdiffusion MRIoptic radiationretinal mappingtractographytractometryvisual system

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Human Anatomy

Background:

  • The optic radiations (OR) transmit visual information from the thalamus to the primary visual cortex (V1).
  • Distinct neural pathways within the OR carry information from foveal, macular, and peripheral visual fields.
  • Understanding the biological properties and aging effects of these specific pathways is crucial for visual neuroscience.

Purpose of the Study:

  • To characterize white matter tissue properties in the foveal, macular, and peripheral segments of the optic radiations.
  • To investigate age-related changes in these distinct visual pathway segments.
  • To compare the aging trajectories of foveal/parafoveal versus peripheral optic radiations.

Main Methods:

  • Utilized diffusion MRI (dMRI) data from a large cohort (N=5382) in the UK Biobank dataset.
  • Employed pyAFQ software for white matter tractometry to analyze optic radiation sub-regions.
  • Quantified tissue properties including fractional anisotropy, mean diffusivity, and mean kurtosis.

Main Results:

  • Foveal and macular OR exhibit higher fractional anisotropy and kurtosis, and lower mean diffusivity than peripheral OR, irrespective of age.
  • Aging is associated with decreased anisotropy and kurtosis, and increased diffusivity in the OR, indicating reduced tissue organization.
  • Anisotropy decreases more rapidly with age in foveal OR compared to peripheral OR, while diffusivity increases faster in peripheral OR.

Conclusions:

  • Distinct biological properties exist between foveal/parafoveal and peripheral optic radiations.
  • Aging differentially impacts the white matter tissue properties of these visual pathway segments.
  • These findings highlight specific vulnerabilities in foveal/parafoveal pathways during the aging process.